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KMID : 0903520060490010021
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2006 Volume.49 No. 1 p.21 ~ p.24
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Cytotoxic Effects of Some Transition Metals, Nickel(II), Copper(II) and Zinc(II), with 3.6-bis(2’-pyridyl)pyridazines Complexes
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Kwon Byung-Mok
Lee Jung-Ock
Choi Sang-Un
Sung Nack-Do
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Abstract
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A series of cytotoxic activities (ED50) in vitro against six human cancers (lung cancer, uterine cancer, skin cancer, brain cancer, colon cancer and adenocarcinoma) and their seventeen cell lines of 3,6-bis(2’-pyridyl)pyridazine, 1, 3,6-bis-(6’-methyl-2’-pyridyl)pyridazine, 2 and their transition metal, Ni(II), Cu(II) and Zn(II) complexes, 3~6 were measured. Particularly, the results revealed that the cytotoxic activities against the brain cancer cell line (SNB-19) and the colon cancer cell line (SW62) of bis-[3,6-bis-(6’-methyl-2’-pyridyl)pyridazine-k2N2,N3]chlorocopper(II)perchlorate, 4 were shown to be higher than that of the first generation anticancer agent, Cis-platin.
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KEYWORD
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3,6-bis(6’-methyl-2’-pyridyl)pyridazine, transition metal complexes, cytotoxic activity, human cancer cell lines
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